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Vidalista 40 mg should not be taken by individuals who are allergic to tadalafil or any of the inactive ingredients in the medication. It is also contraindicated in patients taking nitrates or alpha-blockers, as the combination can cause a significant drop in blood pressure. Patients with certain medical conditions, such as severe heart disease, liver or kidney impairment, or uncontrolled hypertension, should use Vidalista 40 mg with caution and under the guidance of a healthcare provider.